Pathogenetic mechanisms of antiphospholipid antibody production in antiphospholipid syndrome
نویسندگان
چکیده
منابع مشابه
ANTIPHOSPHOLIPID ANTIBODY SYNDROME-A CASE OF AORTIC VALVE INSUFFICIENCY
A 31 year old woman was hospitalized for evaluation of aortic valve insufficiency and her present cardiac status. Clinical and paraclinical findings strongly suggested the presence of a collagen vascular inflammatory processprecisely, the antiphospholipid antibody syndrome (APS), with systemic lupus erythematosus as the underlying disease.
متن کاملAntiphospholipid antibody syndrome.
The 2006 International Consensus Statement on an Update of the Classification Criteria for Definite Antiphospholipid Syndrome has increased the time between the two laboratory studies required for diagnosis from 6 to 12 weeks. Antibody to beta2 glycoprotein 1 has been included as a criterion. Various non-criteria diagnostic clues such as livedo reticularis, heart valve disease, thrombocytopenia...
متن کاملTreatment of antiphospholipid antibody syndrome
Antiphospholipid antibody syndrome (APS) is a systemic autoimmune disease with thrombotic predilection resulting in vascular thrombotic events and obstetric complications. Management of APS focuses on anticoagulation; however, despite the solid evidence suggesting that this is the best treatment option available, a lot of debate persists regarding the intensity and duration of anticoagulation n...
متن کاملPathophysiological mechanisms in antiphospholipid syndrome
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by recurrent thrombosis and fetal loss in the presence of persistently positive antiphospholipid (aPL) antibodies (Abs) including lupus anticoagulant (LAC), IgG/IgM anticardiolipin (aCL) Abs and anti-b2glycoprotein I (b 2 GPI) Abs [1–3]. aPL Abs are a heterogenous group of autoantibodies that react to phospholipids (...
متن کاملMechanisms of thrombosis in the antiphospholipid syndrome
Los pacientes afectos de síndrome antifosfolipídico (SAF) presentan un riesgo aumentado de padecer trombosis venosas y arteriales, pérdidas fetales recurrentes y/o trombocitopenia. Estas manifestacions clínicas se asocian con la presencia de anticuerpos antifosfolipídicos (AAF), entre los que se incluyen los anticuerpos anticardiolipina (aCL) y el anticoagulante lúpico (AL). A pesar de la estre...
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ژورنال
عنوان ژورنال: World Journal of Rheumatology
سال: 2015
ISSN: 2220-3214
DOI: 10.5499/wjr.v5.i2.59